Carl Sagan’s Cosmic Calendar (illustrated as a comic strip here), which maps the entire history of our cosmos onto a single year, witnesses a milestone of evolution in November.  On Nov. 2, we see the emergence of eukaryotes, or cells with nuclei:

“All large complex organisms are eukaryotes, including plants, animals, and fungi.

“…  Eukaryotes represent a tiny minority of all living things; even in a human body there are 10 times more microbes than human cells. However, due to their much larger size their collective worldwide biomass is estimated at about equal to that of prokaryotes.”  (Wikipedia)